In Single Level mode, the player selects one single level and attempts to complete that level for a single high score. In addition, the game features two game modes: Single Level and Arcade. The amount of bonus score depends on various factors, including the number of humans saved and the number of nova-bombs preserved, to name a few. Upon completion of each level, the player will receive a bonus score. You can also choose from a selection of custom made skins for your ship made by other people online. Ship upgrades and extra lives can also be obtained through pickups, or by saving humans. These are limited in quantity but can be obtained through pickups. The nova-bomb produces a large explosion that clears all enemies currently on the level. Boost acts as a speed boost and allows the player to escape from enemies, as well as destroy enemies by colliding with them. Overdrive, once charged, produces a powerful beam of energy that is capable of taking out large quantities of enemies. In addition, various upgrades and powerups are available to the player throughout each level. Three ships (Nemesis, Ferox, and Phobos) are available for selection each ship has different levels of agility, boost, and overdrive. In order to save a human, it must first be released from its chamber by killing a set of 'keepers.' Upon release, the player can pick up the human and bring it to one of two safety points. Although the primary goal of each level is to eliminate all enemies, including the boss, humans can be saved in order to gain a bonus score towards the player's final score. Each level is separated into three phases and includes a unique boss enemy. In Resogun, the player battles phases of enemies on five distinct, cylindrical, voxel-based levels: Acis, Ceres, Decima, Febris, and Mefitis. Here, the player fights off enemies coming from both directions as they wait for the next human to be released. In Resogun, the player battles enemies in a cylindrical, voxel-based world.

Resogun won several awards, and was nominated for Action Game of the Year at the 2014 DICE Awards, and also appeared at the 2014 GDC Choice Awards. The game was criticized for its short length and lack of tutorials or explanations for several gameplay elements. The game was well received by video game journalists, who lauded its graphical prowess, fast-paced gameplay, and soundtrack. In Resogun the player battles enemies and rescues trapped humans in a cylindrical, voxel-based world.

Resogun draws heavily from the games Defender and Datastorm, and is considered the spiritual successor to Housemarque's previous shoot 'em up games Super Stardust HD and Super Stardust Delta. Resogun: Heroes, the first downloadable content (DLC), was released in North America on June 24, 2014, while the second DLC, Resogun: Defenders was released on February 17, 2015. The PlayStation 4 game was released in North America and the PAL region in November 2013 and in Japan in February 2014, while the Vita and PlayStation 3 versions were released in December 2014. Resogun is a voxel-based side-scrolling shoot 'em up video game developed by Finnish developer Housemarque and published by Sony Interactive Entertainment for the PlayStation 4, PlayStation 3 and PlayStation Vita.

Resogun video